Tuesday, 1 June 2010

Supercritical Fluids Chromatography

The Supercritical Fluids Chromatography (SFC) is a kind of chromatography where the mobile phase is a supercritical fluid.
The most used SCF is the carbon dioxide (do not mix-up SCF SuperCritical Fluid and SFC Supercritical Fluid Chromatography).
Then SFC is a normal phase chromatography between the gas chromatography (GC) and the liquid chromatography (HPLC).
The systems are close to an HPLC but with a backpressure regulator to maintain the pressure above the critical pressure.
The stationary phase is in packed columns that can contain differents polar phases .